"We'll make you a pizza you can't refuse"

Top Rated Pizza in Buffalo

Become part of the Mafia today! We're more than just your average pizza place. Wise Guy's Pizza located on Seneca Street in the heart of South Buffalo is family owned and operated for over 25 years. We strive to make great food and provide it quickly with the best customer service possible. We serve our pizzas with our house-made signature sweetened sauce and the highest quality ingredients. We also serve our house-made traditional pizza sauce for those who prefer a less sweet sauce upon request. Some of our popular menu items include pizza, 30 flavors of wings, fried chicken, chicken fingers, calzones, tacos, hoagies, subs, fish, & salads.!

We deliver to South Buffalo, Sloan, Firstward, Lovejoy, West Seneca, Downtown, and Kaisertown

buffalo style chicken wings
Buffalo Style Chicken Wings
buffalo style pizza
Buffalo Style Pizza
delicious side of onion rings
Delicious Sides
Delicious Desserts
Sandwiches, Subs & Hoagies
Weekly Specials

Our Location


1965 Seneca St.
Buffalo, NY 14210

(716) 826-8406

Mon - Wed: 10:00 am - 11:00 pm
Thu - Fri: 10:00 am - 1:00 am
Sat: 3:00 pm - 1:00 am
Sun: 10:00 am - 11:00 pm